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Triglyceride levels and risk of type 2 diabetes mellitus: a longitudinal large study
  1. Amani Beshara1,
  2. Eytan Cohen1,2,
  3. Elad Goldberg1,2,
  4. Pearl Lilos2,
  5. Moshe Garty2,3,
  6. Ilan Krause1,2
  1. 1Department of Internal Medicine, F—Recanati Institute, Petach Tikva, Israel
  2. 2Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  3. 3Recanati Center for Preventive Medicine, Rabin Medical Center, Petach Tikva, Israel
  1. Correspondence to Dr Amani Beshara, Department of Internal Medicine F—Recanati, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel; b.amani{at}


The relationship between triglyceridemia and diabetes mellitus remains unclear. This study evaluated the risk of diabetes and impaired fasting glucose associated with a wide range of triglyceride levels. A longitudinal retrospective study was carried out employing data from a screening center between the years 2000 and 2012. Inclusion criteria were absence of diabetes at baseline and attendance at the center at least twice over a 5-year period. Participants were divided by fasting blood glucose level (normal/impaired) at the first visit. A total of 5085 participants were eligible for the study. Of the 4164 normoglycemic participants at baseline, 40 (0.96%) had diabetes and 998 (24%) had impaired fasting glucose by the end of the study. On stepwise logistic regression analysis, every 10 mg/dL increase in triglyceride level significantly increased the risk of diabetes by 4% and of impaired fasting glucose by 2% (p<0.001). This association held true even when rising triglyceride levels remained within the accepted normal range (<150 mg/dL, p<0.001). Sustained increments in serum triglyceride level, even within the accepted normal range, are an independent risk factor for diabetes mellitus and impaired fasting glucose in normoglycemic participants.

  • Diabetes Mellitus

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