Article Text

PDF
Oxidative challenge in Alzheimer's disease: state of knowledge and future needs
  1. Carlo Cervellati1,
  2. Paul L Wood2,
  3. Arianna Romani1,
  4. Giuseppe Valacchi3,4,
  5. Monica Squerzanti1,
  6. Juana Maria Sanz5,
  7. Beatrice Ortolani5,
  8. Giovanni Zuliani5
  1. 1Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics University of Ferrara, Ferrara, Italy
  2. 2Metabolomics Unit, Math and Science Building, Lincoln Memorial University, Harrogate, Tennessee, USA
  3. 3Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy
  4. 4Department of Food and Nutrition, Kyung Hee University, Seoul, South Korea
  5. 5Department of Medical Science, Section of Internal and CardioRespiratory Medicine, University of Ferrara, Ferrara, Italy
  1. Correspondence to Dr Carlo Cervellati, Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics, University of Ferrara, Via Luigi Borsari 46, Ferrara 44121, Italy; crvcrl{at}unife.it

Abstract

A large body of experimental and postmortem findings indicate that Alzheimer's disease (AD) is associated with increased oxidative stress (OxS) levels in the brain. Despite the current limitations of OxS assessment in living subjects, recent data suggest that oxidative challenge might increase early both in the central nervous system and peripheral fluids. The aim of this review was to provide an overview of the existing literature linking systemic OxS to brain OxS in AD. We firmly believe that continued research aimed at overcoming the methodological and design issues affecting the body of studies in this field is mandatory for successful development of an effective antioxidant-based treatment of AD.

  • Alzheimer Disease
  • Oxidants
  • Biological Markers
  • Antioxidants
  • Dementia

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.