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Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia

Authors

  • Mumtaz Takir From the *Department of Medicine, Division of Endocrinology, †Department of Medicine, ‡Department of Medicine, Division of Nephrology, and §Departments of Biochemistry and ¶Family Medicine, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul; and ∥Department of Medicine, Division of Nephrology, Konya Numune State Hospital, Konya, Turkey; **Division of Renal Diseases and Hypertension, University of Colorado, Denver, CO; and ††Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey. PubMed articlesGoogle scholar articles
  • Osman Kostek From the *Department of Medicine, Division of Endocrinology, †Department of Medicine, ‡Department of Medicine, Division of Nephrology, and §Departments of Biochemistry and ¶Family Medicine, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul; and ∥Department of Medicine, Division of Nephrology, Konya Numune State Hospital, Konya, Turkey; **Division of Renal Diseases and Hypertension, University of Colorado, Denver, CO; and ††Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey. PubMed articlesGoogle scholar articles
  • Abdullah Ozkok From the *Department of Medicine, Division of Endocrinology, †Department of Medicine, ‡Department of Medicine, Division of Nephrology, and §Departments of Biochemistry and ¶Family Medicine, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul; and ∥Department of Medicine, Division of Nephrology, Konya Numune State Hospital, Konya, Turkey; **Division of Renal Diseases and Hypertension, University of Colorado, Denver, CO; and ††Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey. PubMed articlesGoogle scholar articles
  • Omer Celal Elcioglu From the *Department of Medicine, Division of Endocrinology, †Department of Medicine, ‡Department of Medicine, Division of Nephrology, and §Departments of Biochemistry and ¶Family Medicine, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul; and ∥Department of Medicine, Division of Nephrology, Konya Numune State Hospital, Konya, Turkey; **Division of Renal Diseases and Hypertension, University of Colorado, Denver, CO; and ††Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey. PubMed articlesGoogle scholar articles
  • Ali Bakan From the *Department of Medicine, Division of Endocrinology, †Department of Medicine, ‡Department of Medicine, Division of Nephrology, and §Departments of Biochemistry and ¶Family Medicine, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul; and ∥Department of Medicine, Division of Nephrology, Konya Numune State Hospital, Konya, Turkey; **Division of Renal Diseases and Hypertension, University of Colorado, Denver, CO; and ††Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey. PubMed articlesGoogle scholar articles
  • Aybala Erek From the *Department of Medicine, Division of Endocrinology, †Department of Medicine, ‡Department of Medicine, Division of Nephrology, and §Departments of Biochemistry and ¶Family Medicine, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul; and ∥Department of Medicine, Division of Nephrology, Konya Numune State Hospital, Konya, Turkey; **Division of Renal Diseases and Hypertension, University of Colorado, Denver, CO; and ††Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey. PubMed articlesGoogle scholar articles
  • Hasan Huseyin Mutlu From the *Department of Medicine, Division of Endocrinology, †Department of Medicine, ‡Department of Medicine, Division of Nephrology, and §Departments of Biochemistry and ¶Family Medicine, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul; and ∥Department of Medicine, Division of Nephrology, Konya Numune State Hospital, Konya, Turkey; **Division of Renal Diseases and Hypertension, University of Colorado, Denver, CO; and ††Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey. PubMed articlesGoogle scholar articles
  • Ozge Telci From the *Department of Medicine, Division of Endocrinology, †Department of Medicine, ‡Department of Medicine, Division of Nephrology, and §Departments of Biochemistry and ¶Family Medicine, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul; and ∥Department of Medicine, Division of Nephrology, Konya Numune State Hospital, Konya, Turkey; **Division of Renal Diseases and Hypertension, University of Colorado, Denver, CO; and ††Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey. PubMed articlesGoogle scholar articles
  • Aysun Semerci From the *Department of Medicine, Division of Endocrinology, †Department of Medicine, ‡Department of Medicine, Division of Nephrology, and §Departments of Biochemistry and ¶Family Medicine, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul; and ∥Department of Medicine, Division of Nephrology, Konya Numune State Hospital, Konya, Turkey; **Division of Renal Diseases and Hypertension, University of Colorado, Denver, CO; and ††Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey. PubMed articlesGoogle scholar articles
  • Ali Riza Odabas From the *Department of Medicine, Division of Endocrinology, †Department of Medicine, ‡Department of Medicine, Division of Nephrology, and §Departments of Biochemistry and ¶Family Medicine, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul; and ∥Department of Medicine, Division of Nephrology, Konya Numune State Hospital, Konya, Turkey; **Division of Renal Diseases and Hypertension, University of Colorado, Denver, CO; and ††Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey. PubMed articlesGoogle scholar articles
  • Baris Afsar From the *Department of Medicine, Division of Endocrinology, †Department of Medicine, ‡Department of Medicine, Division of Nephrology, and §Departments of Biochemistry and ¶Family Medicine, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul; and ∥Department of Medicine, Division of Nephrology, Konya Numune State Hospital, Konya, Turkey; **Division of Renal Diseases and Hypertension, University of Colorado, Denver, CO; and ††Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey. PubMed articlesGoogle scholar articles
  • Gerard Smits From the *Department of Medicine, Division of Endocrinology, †Department of Medicine, ‡Department of Medicine, Division of Nephrology, and §Departments of Biochemistry and ¶Family Medicine, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul; and ∥Department of Medicine, Division of Nephrology, Konya Numune State Hospital, Konya, Turkey; **Division of Renal Diseases and Hypertension, University of Colorado, Denver, CO; and ††Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey. PubMed articlesGoogle scholar articles
  • Miguel ALanaspa From the *Department of Medicine, Division of Endocrinology, †Department of Medicine, ‡Department of Medicine, Division of Nephrology, and §Departments of Biochemistry and ¶Family Medicine, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul; and ∥Department of Medicine, Division of Nephrology, Konya Numune State Hospital, Konya, Turkey; **Division of Renal Diseases and Hypertension, University of Colorado, Denver, CO; and ††Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey. PubMed articlesGoogle scholar articles
  • Shailendra Sharma From the *Department of Medicine, Division of Endocrinology, †Department of Medicine, ‡Department of Medicine, Division of Nephrology, and §Departments of Biochemistry and ¶Family Medicine, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul; and ∥Department of Medicine, Division of Nephrology, Konya Numune State Hospital, Konya, Turkey; **Division of Renal Diseases and Hypertension, University of Colorado, Denver, CO; and ††Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey. PubMed articlesGoogle scholar articles
  • Richard J. Johnson From the *Department of Medicine, Division of Endocrinology, †Department of Medicine, ‡Department of Medicine, Division of Nephrology, and §Departments of Biochemistry and ¶Family Medicine, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul; and ∥Department of Medicine, Division of Nephrology, Konya Numune State Hospital, Konya, Turkey; **Division of Renal Diseases and Hypertension, University of Colorado, Denver, CO; and ††Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey. PubMed articlesGoogle scholar articles
  • Mehmet Kanbay From the *Department of Medicine, Division of Endocrinology, †Department of Medicine, ‡Department of Medicine, Division of Nephrology, and §Departments of Biochemistry and ¶Family Medicine, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul; and ∥Department of Medicine, Division of Nephrology, Konya Numune State Hospital, Konya, Turkey; **Division of Renal Diseases and Hypertension, University of Colorado, Denver, CO; and ††Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey. PubMed articlesGoogle scholar articles
  1. Reprints: Mumtaz Takir, MD, Goztepe Training and Research Hospital, Department of Medicine, Division of Endocrinology, Kadikoy, Istanbul, Turkey. E-mail: mumtaztakir{at}yahoo.com.
  2. Dr Johnson is an inventor of a patent at the University of Florida on lowering uric acid in the treatment of insulin resistance (US 2014/0107136 A1) that has been licensed to XORT Therapeutics.
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Citation

Takir M, Kostek O, Ozkok A, et al
Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia
Journal of Investigative Medicine 2015;63:924-929.

Publication history

  • Received December 28, 2014
  • Received September 3, 2015
  • Accepted September 4, 2015
  • First published December 15, 2015.
Online issue publication 
December 15, 2015

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