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Vitamin D Levels in Patients With Type 2 Diabetes Mellitus
  1. José María Calvo-Romero, MD,
  2. José Manuel Ramiro-Lozano, MD
  1. From Internal Medicine Service, Hospital Ciudad de Coria, Coria, Cáceres, Spain.
  1. Reprints: José María Calvo-Romero, MD, Internal Medicine Service, Hospital Ciudad de Coria, C/ Cervantes 75, 10800 Coria, Cáceres, Spain. E-mail: jm.calvo{at}orangemail.es.

Abstract

Background Vitamin D may influence many diseases, including type 2 diabetes mellitus.

Patients and Methods We studied serum levels of 25-hydroxyvitamin D (25(OH)D) and associated characteristics in type 2 diabetic outpatients with pharmacologic treatment attended in internal medicine offices in a first-level hospital from Extremadura (Southern Spain).

Results We included a total of 103 patients. Seventy-two patients (69.9%) had serum levels of 25(OH)D lower than 20 ng/mL. There was inverse correlation between serum levels of 25(OH)D and glycosylated hemoglobin (r = −0.74, P = 0.01). In 78 patients without insulin therapy, we found inverse correlation between serum levels of 25(OH)D and fasting serum insulin (r = −0.82, P = 0.001) and Homeostasis Model Assessment–Insulin Resistance (r = −0.51, P < 0.001).

Conclusions Vitamin D deficiency is common in type 2 diabetic patients. There are inverse correlations between vitamin D and metabolic control and insulin resistance.

Key Words
  • type 2 diabetes mellitus
  • insulin resistance
  • vitamin D

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