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Elevated Human Endothelial Cell-Specific Molecule-1 Level and Its Association With Coronary Artery Disease in Patients With Hypertension
  1. Chang Xiong, MD,
  2. Zi-wen Zhao, MD, PhD,
  3. Zhao-yang Chen, MD,
  4. Ling-zhen Wu, MD, PhD,
  5. Yu-kun Luo, MD, PhD,
  6. Fu-dong Hu, MD,
  7. Chao-gui Lin, MD,
  8. Liang-long Chen, MD, PhD, FACC
  1. From the Department of Cardiology, Union Hospital, Fujian Medical University; and Fujian Institute of Coronary Artery Disease, Fuzhou, P.R. China.
  1. Received November 9, 2014, and in revised form May 28, 2015.
  2. Accepted for publication May 31, 2015.
  3. Reprints: Liang-long Chen, MD, PhD, FACC, Department of Cardiology, Union Hospital, Fujian Medical University, 29 Xin-Quan Road, Fuzhou, 350001, P.R. China. E-mail: lianglongchenxh{at}
  4. This work is supported by National Natural Science Foundation of China (81170196) and Fujian Natural Science Foundation for Young Scholars (2013J05114).
  5. The authors declare no conflicts of interest.


Background Endothelial dysfunction plays an important role in the pathophysiology of coronary artery disease (CAD). Previous studies suggested that human endothelial cell-specific molecule-1 (endocan) may be a novel endothelial dysfunction marker. This study aims to investigate the relationship between serum endocan level and the presence and severity of CAD in patients with hypertension.

Methods A total of 190 eligible hypertension patients were enrolled in this study. Serum endocan level was measured by enzyme-linked immunosorbent assay. The presence and severity of CAD were evaluated by coronary angiography.

Results Hypertensive patients with CAD had significantly higher serum endocan level than those without CAD (1.63 ± 0.51 ng/mL vs 1.31 ± 0.65 ng/mL, P < 0.05). Multivariate logistic regression revealed that serum endocan level was independently associated with the presence of CAD (odds ratio, 2.662; 95% confidence interval, 1.560–4.544; P < 0.001). Spearman rank correlation analysis demonstrated that serum endocan level was associated with SYNergy between PCI with TAXUS and Cardiac Surgery score (r = 0.349, P = 0.001).

Conclusions Serum endocan level is independently correlated with the presence and severity of CAD in hypertension patients, and those with high endocan level may have an increased risk of developing atherosclerosis.

Key Words
  • endocan
  • biomarker
  • coronary artery disease
  • hypertension

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