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The Effect of Exercise on Lipid Profiles and Inflammatory Markers in Lean Male Adolescents
  1. Chun-Jui Huang, MD*†,
  2. Chin-Fai Kwok, MD*†,
  3. Chung-Hsing Chou, MD,
  4. Yu-Ching Chou, PhD§,
  5. Low-Tone Ho, MD,
  6. Kuang-Chung Shih, MD, PhD
  1. From the *Division of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital; †Department of Medicine, National Yang-Ming University; ‡Department of Neurology, Tri-Service General Hospital; §School of Public Health, National Defense Medical Center; ∥Department of Medical Research, Taipei Veterans General Hospital; and ¶Division of Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
  1. Received February 24, 2014, and in revised form September 28, 2014.
  2. Accepted for publication September 29, 2014.
  3. Reprints: Kuang-Chung Shih, MD, PhD, Division of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, 201, Sec. 2, Shih-Pai Rd, Taipei 112, Taiwan. E-mail: kcshih{at}vghtpe.gov.tw.
  4. Supported partly by funding received from the Tri-Service General Hospital (TSGH-C96-5-S03), Taipei, Taiwan, and the National Health Research Institutes (BS-096-PP-01), Zhunan, Miaoli County, Taiwan.
  5. None of the authors has any conflicts of interest.

A Prospective Interventional Study

Abstract

Background Physical activity improves body composition and inflammatory markers in obese individuals, but little is known about the nonobese population.

Objective The aim of this study was to investigate associations between exercise and inflammatory cytokines in lean male adolescents in Taiwan.

Methods This interventional study enrolled a total of 79 normal body weight male adolescents [mean age, 16.8 (1.0) years] from the Army Academy of Taiwan. Body composition and inflammatory markers were measured at baseline and upon completion of a 12-week exercise intervention program.

Results Subjects’ postintervention anthropometric measures, including waist circumference [74.6 (5.2) → 72.6 (5.2) cm], hip circumference [92.3 (4.1) → 89.9 (5.0) cm], body fat mass [10.2 (3.2) → 8.2 (3.2) kg], and body fat percentage [15.8% (4.2) → 12.6 (4.5)%] declined significantly compared to preintervention (all P < 0.001), as did systolic blood pressure (P = 0.002) and mean blood pressure (P = 0.020). Postintervention body height and free fat mass increased significantly (both P < 0.001). Subjects’ postintervention lipids including total cholesterol, low-density lipoprotein, high-density lipoprotein, and triglycerides increased significantly (all P < 0.001). Inflammatory markers including adiponectin [14.32 (6.68) → 31.31 (30.53) μg/mL, P < 0.001], interleukin 6 [2.15 (4.81) → 2.86 (6.37) pg/mL, P = 0.005], and C-reactive protein [1.00 (2.57) → 2.30 (4.17) μg/mL, P < 0.001] increased significantly postintervention, but not leptin.

Conclusions Exercise training significantly improves body composition and anti-inflammatory adiponectin levels in lean male adolescents.

Key Words
  • adiponectin
  • inflammatory cytokines
  • exercise
  • adolescent

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