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Are Human Adenovirus-5 and 36 Associated With Obesity in Children?
  1. Elcin Kal Cakmakliogullari, MD*,
  2. Tamer Sanlidag, PhD,
  3. Betul Ersoy, MD,
  4. Sinem Akcali, MD,
  5. Ahmet Var, MD§,
  6. Candan Cicek, MD
  1. From the *Department of Medical Microbiology, Karabuk State Hospital; Departments of †Medical Microbiology, ‡Pediatrics, and §Medical Biochemistry, Faculty of Medicine, Celal Bayar University, Manisa; and ∥Department of Medical Microbiology, Faculty of Medicine, Ege University, Ýzmir, Turkey.
  1. Received August 5, 2013, and in revised form February 22, 2014.
  2. Accepted for publication February 24, 2014.
  3. Reprints: Tamer Sanlidag, PhD, Department of Medical Microbiology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey. E-mail: trsanlidag{at}yahoo.com.
  4. Supported by Celal Bayar University grant 2010021.

Abstract

Objectives The aims of this study were to determine the association between adenovirus-5– and adenovirus-36–specific antibodies and obesity in children and to investigate their relationship with serum lipid and leptin levels.

Methods A cross-sectional study was performed on a total of 120 children who were divided into subgroups according to body mass index percentile as obese (≥95th percentile) or nonobese (<95th percentile). The presence of adenovirus-36 and adenovirus-5–neutralizing antibodies was investigated by using the serum neutralization assay. Serum leptin levels were determined by microenzyme immonoassay; high-density lipoprotein, low-density lipoprotein, triglyceride, and cholesterol levels were measured by chemiluminescence method.

Results The presence of adenovirus-5–specific antibodies was 28.3% and 6.6% in the obese children and in non–obese children, respectively (P = 0.02). The frequency of adenovirus-36–specific antibodies was significantly greater (P = 0.018) in the obese children (26.6%) than in the non–obese children (10.0%). Serum leptin level of the obese group were significantly higher than that of the non–obese group (P = 0.000).

Conclusions Our data support the association between obesity and the presence of specific antibodies to adenovirus-36 and adenovirus-5 in children. Our research has the feature of being the first national study to indicate the relationship between adenovirus-36 and human obesity as well as the first international study to indicate the relationship between adenovirus-5 and human obesity.

Key Words
  • obesity
  • children
  • adenovirus serotypes
  • microneutralization assay
  • lipid profiles

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