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Evaluation of the Glutamine 27 Glutamic Acid Polymorphism in the Adrenoceptor β2 Surface Gene on Obesity and Metabolic Phenotypes in Taiwan
  1. Tun-Jen Hsiao, MD, PhD*,
  2. Eugene Lin, PhD†‡
  1. From the *College of Public Health and Nutrition, Taipei Medical University; and †Vita Genomics, Inc, Taipei; and ‡Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan.
  1. Received May 3, 2013, and in revised form October 10, 2013.
  2. Accepted for publication October 22, 2013.
  3. Reprints: Eugene Lin, PhD, Vita Genomics, Inc, 7 Fl., No. 6, Sec. 1, Jung-Shing Rd, Wugu Shiang, Taipei, Taipei Taiwan. E-mail: eugene.lin{at}vitagenomics.com.
  4. Funding was provided by Vita Genomics, Inc, and SBIR grants from the Department of Economic Affairs in Taiwan.
  5. The authors have no conflicts of interest that are directly relevant to the content of this study.

Abstract

Background The single-nucleotide polymorphism (SNP), rs1042714 or glutamine 27 glutamic acid (Gln27Glu), in the adrenoceptor β2 surface (ADRB2) gene has previously been examined for association with obesity with inconclusive results. The objective of this study was to determine whether the ADRB2 rs1042714 SNP could influence obesity and obesity-related metabolic traits in a Taiwanese population.

Methods The ADRB2 rs1042714 SNP and obesity-related metabolic traits including blood pressure, total cholesterol, triglyceride, fasting glucose, waist circumference, and body mass index (BMI) were examined in 967 individuals with general health examinations.

Results Our data revealed that the ADRB2 rs1042714 SNP exhibited a significant association with obesity among the subjects (P = 0.021). Furthermore, the carriers of the GG genotype had a significantly higher BMI than those with the CC genotype (26.0 ± 5.6 vs 24.3 ± 3.8 kg/m2; P = 0.009) and those with the CG genotype (26.0 ± 5.6 vs 23.6 ± 3.3 kg/m2; P = 0.001). We also found a nominal association with systolic blood pressure (P = 0.058) and triglyceride (P = 0.055) levels in the ADRB2 rs1042714 SNP.

Conclusions Our study indicates that the ADRB2 rs1042714 SNP may contribute to the risk of obesity and predict obesity-related metabolic traits such as BMI, triglyceride, and systolic blood pressure in Taiwanese subjects.

Key Words
  • β2-adrenergic receptor
  • metabolic phenotypes
  • obesity
  • single-nucleotide polymorphisms

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