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A Cut-Point Value of Uncarboxylated to Carboxylated Index Is Associated With Glycemic Status Markers in Type 2 Diabetes
  1. José Rafael Villafán-Bernal, MD, PhD*,
  2. Mara Anaís Llamas-Covarrubias, PhD,
  3. José Francisco Muñoz-Valle, PhD,
  4. Edgar Alfonso Rivera-León, PhD*,
  5. Mercedes Elvira González-Hita, PhD*,
  6. Blanca Estela Bastidas-Ramírez, PhD§,
  7. Carmen Magdalena Gurrola-Díaz, PhD§,
  8. Juan Socorro Armendáriz-Borunda, PhD,
  9. Sergio Sánchez-Enríquez, MD, PhD, MSc*
  1. From the *Cuerpo Académico UDG-CA-533 de Investigación en Bioquímica, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara; †Servicio de VIH, Hospital Civil Fray Antonio Alcalde; and ‡Grupo de Inmunogenética Funcional and §Instituto de enfermedades crónico-degenerativas, Departamento de Biología Molecular y Genómica, and ∥Instituto de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México.
  1. Received June 4, 2013, and in revised form September 5, 2013.
  2. Accepted for publication September 7, 2013.
  3. Reprints: Sergio Sánchez-Enríquez, MD, PhD, MSc, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, C.P. 44340 Guadalajara, Jalisco, México. E-mail: serlucis{at}hotmail.com; serlucis{at}yahoo.com.
  4. This study was supported by the grant Redes PROMEP-SEP awarded to S.S.-E.
  5. The authors have no conflicts of interest to declare.

Abstract

Background The uncarboxylated osteocalcin (ucOC) has been described as a regulator of glucose metabolism in mice, and it is decreased in human type 2 diabetes mellitus (T2D). Although inversely correlated with serum glucose, insulin, and glycated hemoglobin, it is unclear if ucOC decrement is caused by diabetes or plays a role in the pathogenesis and/or progression of the disease. Whatever the case may be, diabetes affects osteoblast gene expression, and possibly the proportion of ucOC over carboxylated OC (cOC). The association of ucOC/cOC index with glycemic status markers in patients with T2D has not been described before.

Objective The objective of this study was to assess the ucOC/cOC index and its relationship with glycemic status markers in patients with T2D.

Methods The ucOC/cOC index was determined by the quotient of ucOC and cOC serum levels in 80 T2D patients and 160 healthy subjects. The relationship between the ucOC/cOC index and glycemic status markers was evaluated.

Results The ucOC/cOC index was low and negatively correlated to fasting plasma glucose and homeostasis assessment-insulin resistance model in T2D patients. The odds ratio for T2D patients with an ucOC/cOC index below the cut-point obtained by receiver operating characteristic analysis was 12.64 (confidence interval, 5.75–27.77; P < 0.001).

Conclusions A value of ucOC/cOC index less than 0.3 is associated with markers of poor metabolic control in patients with T2D.

Key Words
  • glucose
  • bone
  • metabolism
  • insulin
  • diabetes
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