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Thursday, January 23, 2014
1 DEVELOPMENT OF A PLLA-BASED BIORESORBABLE STENT FOR USE IN CONGENITAL HEART DISEASE
Ni J1, Seger C2, Alexy R1, Wu B2, Levi D1. 1UCLA, Los Angeles, CA and 2UCLA, Los Angeles, CA.
Purpose of Study: Stents used in the treatment of congenital heart disease (CHD) only need to serve as temporary scaffolding due to growing cardiovascular structures. Thus, bioresorbable stents are a promising alternative to open chest surgery in the treatment of CHD, such as coarctation of the aorta. Bioresorbable stents, in contrast with traditional metal stents, are completely absorbed by the body after providing the necessary support. This project aims to design a bioresorbable stent for the treatment of congenital heart lesions in neonates and infants.
Methods Used: Poly-L-lactic acid (PLLA) and PLLA-blend tubes were fabricated using sputter deposition on a custom-built robot and tested for radial strength. Tubes laser-cut into desired stent geometry were crimped down on a balloon catheter for stent delivery. Due to crimping fractures, FEM stress analysis (Autodesk Inventor 2014) was conducted on the initial stent geometry to locate regions of concentrated stress and guide development of revised geometry.
Summary of Results: A sputter deposition based protocol for fabricating PLLA-based bioresorbable stents for the treatment of congenital heart disease was developed and refined. Tubes of PLLA and PLLA blends were successfully laser-cut into stents and tested for radial strength and ability to be crimped and deployed. Using FEM stress analysis, the stent geometry was modified with curve and row intersection optimizations for better stress distribution, reducing risk of fracture when crimped.
Conclusions: We have made progress in the development of a novel PLLA-based bioresorbable stent through fabrication and geometry optimization. Future steps involve refining polymer blends, crimping and heat-setting, and degradation profile.
2 MESENCHYMAL STEM CELLS AS CELL BASED THERAPIES IN HEART FAILURE
Pandey AC1, Lancaster J …
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