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Abstracts from the 2013 International Conference on Biomedicine and Pharmacology

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Gang Li. School of Mechanical and Electrical Engineering, East China Jiaotong University, Nanchang 330013, China.


Background: When a foreign material is exposed to blood, we firstly observe the adsorption of plasma proteins, followed by the activation of clotting factors or the adhesion and activation of platelets, and finally the formation of a non-soluble fibrin network or thrombus. Biomaterials should be chemically and biologically inert to the surrounding cells and body fluids. Therefore, in order to improve the blood compatibility of biomaterial, various techniques such as chemical vapor deposition, magnetron sputtering and plasma immersion ion implantation deposition have been applied to modify the surface for preventing thrombus formation. It has been thought that the interaction between the surface of the artificial biomaterial and biological environment is a key factor to determine the biocompatibility of materials. The relationship between the physicochemical state of surface and blood compatibility of the materials is of topical concern.

Methods: Polydimethylsiloxane (PDMS) textured surface with parallel grating micro-structure were designed and fabricated by soft lithography. The morphology of textured surface is observed by using scanning eletron microscopy (SEM). Water contact angles were measured by using contact angle meter to characterize the wettabilities of the textured surface and the blood platelet adhesion test was carried out to study the blood comatibility of the surface.

Results: The contact angle results indicate that the average ccontact angle with water is about 114.7° for smooth PDMS treated silylation and about 161.8° for the textured surface. The blood platelet adhesion experiment results showed that the platelet aggregated, deformed and produced pseudopodia on the smooth surface. But on the textured surface, the number of the adhered platelet was less than that of flat surface. They also kept a normal shape without significant pseudopodium and aggregation.

Conclusion: This textured surface …

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