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Serum 25-Hydroxyvitamin D Level Is Associated With Arterial Stiffness, Left Ventricle Hypertrophy, and Inflammation in Newly Diagnosed Hypertension
  1. Osman Kuloğlu, MD*,
  2. Mustafa Gür, MD*,
  3. Taner Şeker, MD*,
  4. Gülhan Yüksel Kalkan, MD*,
  5. Durmuş Yıldıray Şahin, MD*,
  6. İbrahim Halil Tanboğa, MD,
  7. Nermin Yıldız Koyunsever, MD*,
  8. Hazar Harbalıoğlu, MD*,
  9. Caner Türkoğlu, MD*,
  10. Selahattin Akyol, MD*,
  11. Zafer Elbasan, MD*,
  12. Armağan Acele, MD*,
  13. Murat Çaylı, MD*
  1. From the *Department of Cardiology, Adana Numune Training and Research Hospital, Adana; and †Department of Cardiology, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
  1. Received February 3, 2013, and in revised form April 4, 2013.
  2. Accepted for publication April 15, 2013.
  3. Reprints: Durmuş Yıldıray Şahin, MD, Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey. E-mail: dysahin79{at}hotmail.com.

Abstract

Objectives Vitamin D may modulate vascular inflammation, vascular smooth muscle cell proliferation, the renin-angiotensin system, and cardiomyocyte proliferation, myocardial fibrosis, and proliferation. These mechanisms may play a role on arterial stiffness and left ventricle hypertrophy (LVH) in hypertensive patients. We aimed to evaluate the association between serum vitamin D with arterial stiffness and LVH in patients with hypertension.

Methods We studied 133 patients with newly diagnosed hypertension [mean (SD) age, 62.9 (10.6) years]. Pulse wave velocity (PWV), which reflects arterial stiffness, was calculated using the single-point method via the Mobil-O-Graph ARCsolver algorithm. Left ventricular mass index (LVMI) was determined according to Deverux formula. The patients were divided into the following 2 groups according to serum vitamin D level: vitamin Dlow group with less than 20 ng/mL and vitamin Dhigh group with greater than or equal to 20 ng/mL.

Results The highest PWV, high-sensitivity C reactive protein, and LVMI values were observed in vitamin Dlow group compared with vitamin Dhigh group. Multiple linear regression analysis showed that vitamin D level was independently associated with LVMI (β = −0.235, P = 0.002) and PWV (β = −0.432, P < 0.001). Adjustment for age, sex, parathyroid hormone level, body surface area, and mean blood pressure did not modify these associations. Vitamin D level was also independently associated with high-sensitivity C reactive protein (β = −0.143, P = 0.047). However, adjustment for parathyroid hormone level or body surface area and mean blood pressure attenuate this association.

Conclusions Serum 25-hyroxyvitamin D is independently related with arterial stiffness, LVH, and inflammation. Vitamin D may play a role on pathogenesis of arterial stiffness and LVH in patient with newly diagnosed hypertension.

Key Words
  • vitamin D
  • pulse wave velocity
  • aortic stiffness
  • hypertension

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