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Serum S100A12 Levels Are Correlated With the Presence and Severity of Coronary Artery Disease in Patients With Type 2 Diabetes Mellitus
  1. Peng Zhao, MD*,
  2. Mingchun Wu, MD, PhD,
  3. Houyou Yu, MD, PhD*,
  4. Yang Huang, MD, PhD*,
  5. Yutong Wang, MD, PhD*,
  6. Wei Wang, MD*,
  7. Wen Yin, MD*
  1. From the *Department of Emergency Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, PR China; and †Department of Anaesthesiology, Wuhan General Hospital of Guangzhou Command, Wuhan, PR China.
  1. Received January 10, 2013, and in revised form March 7, 2013.
  2. Accepted for publication March 10, 2013.
  3. Reprints: Wen Yin, MD, Department of Emergency Medicine, Xijing Hospital, Fourth Military Medical University, 17 Changle West Rd, 710032, Xi’an, Shanxi, PR China. E-mail: xijingyinwen{at}
  4. Peng Zhao and Mingchun Wu contributed equally to this paper and should be considered as co–first authors.
  5. The authors report no conflict of interest.


Objective Patients with type 2 diabetes mellitus (T2DM) are at high risk for development of atherosclerosis and cardiovascular events. Serum S100A12 levels have been reported to be associated with coronary artery disease (CAD) and T2DM. We sought to assess whether serum S100A12 levels are correlated with the presence and severity of CAD.

Methods Type 2 diabetes mellitus levels in 188 consecutive patients with T2DM undergoing coronary angiography for the evaluation of CAD. The severity of CAD was assessed by the Coronary Atherosclerosis Index (CAI) scores.

Results Serum S100A12 levels were significantly higher in patients with T2DM with CAD than in those without CAD. Multivariate logistic regression analysis revealed that serum S100A12 levels were independently associated with the presence of CAD. Serum S100A12 levels were positively correlated with the Coronary Atherosclerosis Index scores after adjusting for other clinical characteristics.

Conclusion High S100A12 levels are associated with the presence and severity of CAD in patients with T2DM.

Key Words
  • S100A12
  • biomarker
  • type 2 diabetes mellitus
  • coronary atherosclerosis index

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