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Myeloperoxidase and Risk of Recurrence of Atrial Fibrillation After Catheter Ablation
  1. Shuai-bing Li, MD*,
  2. Fan Yang, MD*,
  3. Li Jing, MD*,
  4. Juan Ma, MD*,
  5. Ya-dan Jia, MD*,
  6. Shao-ying Dong, MD*,
  7. Wei-feng Zheng, MD,
  8. Luo-sha Zhao, MD*
  1. From the Departments of *Cardiology, and †Cardiovascular Surgery, The First Affiliated Hospital of Zhengzhou University, Henan, China.
  1. Received November 1, 2012, and in revised form December 1, 2012.
  2. Accepted for publication December 19, 2012.
  3. Reprints: Luo-sha Zhao, MD, Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Rd, Zhengzhou 450052, Henan Province, China. E-mail: zls319{at}zzu.edu.cn.
  4. Supported by research grants from the Department of Cardiology of The First Affiliated Hospital of Zhengzhou University, the Department of Clinical Laboratory of The First Affiliated Hospital of Zhengzhou University, and the Key disciplines Laboratory Clinical-Medicine Henan.
  5. The authors have no conflicts of interest.

Abstract

Background Myeloperoxidase (MPO) has been associated with the development of atrial fibrillation (AF), but its impact on the recurrence of AF after catheter ablation has not been explored. This study investigated the effect of plasma MPO on recurrence after catheter ablation of paroxysmal AF.

Methods and Results Two hundred eighty-eight consecutive patients with paroxysmal AF and who underwent circumferential pulmonary vein isolation were prospectively enrolled. After a mean ± SD follow-up of 516 ± 204 (91–910) days, the recurrence rates were 16.9%, 25.7%, 29.7%, and 38.0% from the lowest MPO quartile to the highest MPO quartile, respectively (P = 0.023). After adjustment for age, sex, left atrial diameter, high-sensitivity C-reactive protein, and pulmonary vein isolation, there was an increased risk of recurrence in the subjects with the highest MPO quartile compared with those with the lowest quartile (hazard ratio, 3.18; 95% confidence interval, 2.12–5.23; P = 0.024). As a continuous variable, MPO was also an independent predictor of recurrence (hazard ratio, 2.12; 95% confidence interval, 1.71–3.27; P = 0.032).

Conclusions Patients with high MPO levels were at an increased risk of AF recurrence after catheter ablation.

Key Words
  • atrial fibrillation
  • catheter ablation
  • recurrence
  • myeloperoxidase

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