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The rs9939609 Gene Variant in FTO Modified the Metabolic Response of Weight Loss After a 3-Month Intervention With a Hypocaloric Diet
  1. Daniel Antonio de Luis, MD*,
  2. Rocío Aller, MD*,
  3. Rosa Conde, PhD*,
  4. Olatz Izaola, PhD*,
  5. Manuel Gonzalez Sagrado, MD*,
  6. Javier Castrodeza Sanz, MD
  1. From the *Center of Investigation of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid,Valladolid, Spain; and †Department of Health Public Medicine, University ofValladolid, Valladolid, Spain.
  1. Received June 13, 2012, and in revised form September 1, 2012.
  2. Accepted for publication September 23, 2012.
  3. Reprints: Daniel Antonio de Luis, MD, Center of Investigation of Endocrinology and Nutrition, Medicine School, University of Valladolid, C/Los perales 16, Simancas 47130, Valladolid, Spain. E-mail: dadluis{at}
  4. Daniel Antonio de Luis was responsible for designing the study and writing the article; Rocío Aller, Olatz Izaola, and Beatriz de la Fuente, for nutritional intervention; Rosa Conde, Manuel Gonzalez Sagrado, and David Primo, for laboratory analysis; and J Castrodeza, for statistical analysis.


Background Common polymorphisms in the fat mass and obesity associated gene (FTO) have been linked to obesity in some populations. Nevertheless, the role of FTO variants on body weight response after dietary intervention remains equivocal.

Objective We decided to analyze the effects of the rs9939609 FTO gene polymorphism on body weight changes and metabolic parameters after 3 months of a hypocaloric diet.

Design Before and after 3 months on a low-fat hypocaloric diet, a white population of 106 subjects with obesity was analyzed.

Results Of the study subjects, 35 (33%) had the genotype TT and 71 (67%) had the next genotypes; TA (46 study subjects, 43.4%) or AA (25 study subjects, 23.6%). After dietary treatment and in TT group, weight, waist circumference, total cholesterol, LDL-cholesterol, insulin, and homeostasis model assessment decreases were less than subjects carrying the A allele [−3.1 (3.6) vs −2.4 (4.1) kg: P < 0.05], waist circumference [−5.4 (6.4) vs −2.6 (4.8) cm; P < 0.05], total cholesterol [−12.3 (35.3) vs −6.4 (4.7) mg/dL; P < 0.05], LDL-cholesterol [−22.3 (30.5) vs −10.7 (30.5) mg/dL; P < 0.05], insulin [−1.89 (5.5) vs +0.94 (8.2) mUI/L; P < 0.05], and homeostasis model assessment [−0.46 (1.11) vs −0.01 (2.4); P < 0.05].

Conclusions Our study confirmed a higher weight loss in A carriers of FTO rs9939609 polymorphism than in TT genotype study subjects.

Key Words
  • adipokines
  • rs9939609 gene variant
  • hypocaloric diet
  • obesity

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