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The Value of Osteopontin in the Assessment of Bone Mineral Density Status in Postmenopausal Women
  1. Daniela Fodor, MD, PhD*,
  2. Cosmina Bondor,
  3. Adriana Albu, MD, PhD*,
  4. Siao-pin Simon, MD, PhD,
  5. Alexandra Craciun, MD, PhD§,
  6. Laura Muntean, MD, PhD
  1. From the *Second Internal Medicine Department, †Medical Informatics and Biostatistics Department, ‡Rheumatology Department, and §Biochemistry Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  1. Received May 9, 2012, and in revised form September 23, 2012.
  2. Accepted for publication September 24, 2012.
  3. Reprints: Laura Muntean, MD, PhD, Rheumatology Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania, 2-4 Clinicilor str, 400006 Cluj Napoca, Romania. E-mail: lmuntean13{at}yahoo.com.
  4. Supported by funds from ANCS (Romanian National Authority for Scientific Research) 42107/2008 PNII grant.
  5. The authors declare that no funding received for this work from any of the following organizations: National Institutes of Health (NIH); Wellcome Trust; and Howard Hughes Medical Institute (HHMI).
  6. The authors have no conflicts of interest.
  7. Authors’ contributions to this work: DF: conceptualization, design, interpretation, and coordination of the work, and writing the manuscript; CB: execution of the statistical analysis and interpretation of the study; AA: recruitment of subjects, revision of the manuscript; SS: execution of BMD; AC: execution of biochemical studies and interpretation of the results; LM: execution of BMD, revision of the manuscript, corresponding author.

Abstract

Background Osteopontin (OPN) has been implicated in bone remodeling by activating the resorption process. We aimed to study the relationship between OPN, bone mineral density (BMD), bone turnover markers, vitamin D, and osteoporotic vertebral fractures in postmenopausal women.

Materials and Methods Serum levels of OPN, osteocalcin, collagen type 1 cross-linked C-telopeptide (CTX), bone alkaline phosphatase, and vitamin D were assessed in 214 postmenopausal women. Bone mineral density was assessed by dual-energy x-ray absorptiometry in lumbar spine and femoral neck, and osteoporotic vertebral fractures by radiographs.

Results Osteopontin levels were significantly higher in osteoporosis group versus osteopenic and normal group (all P < 0.05). The cutoff values of OPN for osteoporosis diagnosis were of 9.47 μg/L at the lumbar spine (area under the curve, 0.67; 95% confidence interval, 0.58–0.75; P < 0.001) and 10.15 μg/L at the femoral neck (area under the curve, 0.69; 95% confidence interval, 0.624–0.77; P = 0.0001), respectively. Postmenopausal women with osteoporosis-related vertebral fractures had significantly higher levels of OPN than those without vertebral fractures (15.69 ± 13.26 vs 12.63 ± 12.46 μg/L; P = 0.02). Significant negative correlations were found between OPN and BMD, which persisted after the adjustment for age at the lumbar spine. Osteopontin levels were directly correlated with bone turnover markers (osteocalcin, bone alkaline phosphatase, and CTX). No significant correlation was found between OPN and vitamin D. Multiple regression analysis showed that age, waist circumference, and CTX were independent predictors of serum OPN levels.

Conclusions High levels of OPN in postmenopausal women are associated with low BMD, increased levels of bone turnover markers, and osteoporotic vertebral fractures. These findings suggest that OPN might play some role in the pathophysiology of postmenopausal osteoporosis and warrant further clinical investigations.

Key Words
  • osteopontin
  • bone mineral density
  • osteoporotic vertebral fracture
  • bone turnover markers
  • vitamin D

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