Article Text
EB Symposium Manuscript
Insulin Signaling and Insulin Resistance
Abstract
Insulin resistance or its sequelae may be the common etiology of maladies associated with metabolic syndrome (eg, hypertension, type 2 diabetes, atherosclerosis, heart attack, stroke, and kidney failure). It is thus important to understand those factors that affect insulin sensitivity. This review stems from the surprising discovery that interference with angiotensin signaling improves insulin sensitivity, and it provides a general overview of insulin action and factors that control insulin sensitivity.
- insulin resistance
- metabolic syndrome
- insulin sensitivity
- angiotensin
- cross talk