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Prevalence of Helicobacter pylori in Patients With Brucellosis
  1. Ramazan Esen, MD*,
  2. Ahmet Cumhur Dulger, MD,
  3. Huseyin Begenik, MD*,
  4. Levent Demirtas, MD,
  5. Senar Ebinc, MD*,
  6. Enver Aytemiz, MD*,
  7. Mahmut Sunnetcioglu, MD§,
  8. Mehmet Aslan, MD*
  1. From the *Departments of Internal Medicine and †Gastroenterology, School of Medicine, Yuzuncu Yil University; ‡Department of Internal Medicine, Ipekyol State Hospital; and §Department of Infectious Disease and Clinical Microbiology, Medical Faculty, Yuzuncu Yıl University, Van, Turkey.
  1. Received February 21, 2012, and in revised form April 8, 2012.
  2. Accepted for publication April 19, 2012.
  3. Reprints: Mehmet Aslan, MD, Department of Internal Medicine, School of Medicine, Yuzuncu Yil University, 65000 Van, Turkey. E-mail: m.aslan301{at}mynet.com.
  4. The authors have no conflict of interest regarding this work.

Abstract

Background Helicobacter pylori infection affects approximately 40 million individuals in Turkey. Our prefecture is an endemic area for H. pylori infection and brucellosis. However, there are no data on the H. pylori prevalence among patients with brucellosis.

Objectives The primary aim of the current study was to investigate the link between H. pylori infection and brucellosis. The secondary aim was to determine the seroprevalence of H. pylori infection in healthy individuals.

Methods Between May 2010 and May 2011, serum was collected from patients with Brucella infection (n = 111) and healthy individuals (n = 120) and analyzed using an enzyme-linked immunosorbent assay kit. Brucella infection was defined as a positive Wright test or blood culture positivity for Brucella in conjunction with disease symptoms and findings.

Results Among the 111 patients with brucellosis, 69% (n = 77) had a seropositivity result for H. pylori IgG. The healthy control subjects had an 87% (n = 104) seropositivity for H. pylori IgG. The serum H. pylori IgG antibody seropositivity was significantly lower in the patients with Brucella infection compared with the control subjects (P < 0.001).

Conclusion Our results show that the serum prevalence of H. pylori among the patients infected with brucellosis is significantly lower than that in the control population. A negative correlation between H. pylori infection and brucellosis infection might be hypothesized.

Key Words
  • Helicobacter pylori
  • brucellosis
  • prevalence
  • IgG antibody
  • Turkey

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