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Association Between Resistin Level and Renal Function in Patients Undergoing Coronary Artery Bypass Graft Surgery

Abstract

Aim The purpose of this study was to evaluate the association between resistin levels and renal function in patients undergoing coronary artery bypass graft (CABG) surgery.

Methods Thirty-seven consecutive patients (mean ± SD, age 60 ± 10 years, 29 (78%) male) undergoing CABG surgery at our department were enrolled into our study. Blood samples were taken to examine quantities of resistin level and other blood parameters the day before surgery. The patients were categorized into 2 groups: lower resistin level (group 1) or higher resistin level (group 2) according to the median value of 9 ng/mL.

Results Mean ± SD resistin level, glomerular filtration rate (GFR), and urea and creatinine levels were 9.5 ± 4.2 ng/mL, 78 ± 25 mL/min per 1.73 m2, 42 ± 14 mg/dL, and 1.08 ± 0.2 mg/dL, respectively. Resistin showed significant correlation with serum levels of urea (r = 0.448l P = 0.005), creatinine (r = 0.367; P = 0.026), inverse correlation with GFR (r = −0.398; P = 0.015), statin usage (r = −0.393; P = 0.016), and β-blocker usage (r = −0.365; P = 0.026). In the multivariate logistic regression model, only GFR (odds ratio, 0.960; 95 confidence interval, 0.928-0.993; P = 0.018) remained independently associated with higher resistin levels after adjustment of other potential confounders in patients undergoing CABG surgery. According to the receiver operating characteristics curve analysis, the optimal cutoff value of GFR to predict higher resistin levels was found as 91 mL/min or less per 1.73 m2, with 100% sensitivity and 61.1% specificity.

Conclusion The present study demonstrated that a lower glomerular filtration rate was associated with higher circulating resistin levels, independent of coronary heart disease risk factors in patients undergoing CABG surgery.

Key Words
  • coronary artery bypass graft surgery
  • renal function
  • resistin

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