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Angiotensin II–Mediated Left Ventricular Abnormalities in Chronic Kidney Disease
  1. Veena Raizada, MD*,
  2. Dustin Hillerson, BS, NREMT-P*,
  3. Jaya Sheela Amaram, MD*,
  4. Betty Skipper, PhD
  1. From the Departments of *Internal Medicine and †Family and Community Medicine, University of New Mexico, Albuquerque, NM.
  1. Received September 9, 2011, and in revised form January 18, 2012.
  2. Accepted for publication January 23, 2012.
  3. Reprints: Veena Raizada, MD, Departments of Internal Medicine, and Family and Community Medicine, MSC 10-5550, 1 University of New Mexico, Albuquerque, NM 87131-0001. E-mail: vraizada{at}salud.unm.edu.
  4. The authors have no disclosures to declare.

Abstract

Angiotensin II (ATII), the biologically active product of the renin-angiotensin system (RAS), is involved in modulation of left ventricular (LV) structure and function in chronic kidney disease (CKD). Because the RAS system is overactive in CKD, excess ATII accumulates in the heart, thereby promoting myocyte hypertrophy, fibroblast proliferation, interstitial accumulation of collagen, and microvessel disease. These cardiac abnormalities are further enhanced by a possible interaction between enhanced RAS activity and hypercalcemia, hyperphosphatemia and secondary hyperparathyroidism, and vitamin D deficiency. The ATII-associated stimulation of aldosterone production from the adrenal gland and the increase in activity of the sympathetic system in CKD, further contribute to LV abnormalities. Myocardial structural changes are major determinants of an increase in myocardial stiffness, leading to LV diastolic and systolic function impairment, and clinical congestive heart failure. Other complications include cardiac conduction disturbances, QT prolongation, and arrhythmias, which all contribute to elevated cardiovascular mortality in patients with CKD.

Key Words
  • RAS
  • ATII
  • CKD
  • LV

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