Article Text

PDF
FTO Gene Polymorphisms and Platelet Counts in a General Japanese Population
  1. Kazuhiko Kotani, MD, PhD*†,
  2. Shinji Fujiwara, MD, PhD*,
  3. Kokoro Tsuzaki*,
  4. Naoki Sakane, MD, PhD*
  1. From the *Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto; and †Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke-City, Tochigi, Japan.
  1. Received July 22, 2011, and in revised form September 5, 2011.
  2. Accepted for publication October 20, 2011.
  3. Reprints: Kazuhiko Kotani, MD, PhD, Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, 1-1 Fukakusa Mukaihata-cho, Fushimi-ku, Kyoto 612-8555, Japan. E-mail: kazukotani{at}jichi.ac.jp.
  4. This study was supported in part by a Grant-in-Aid for the Foundation for the Development of the Community, Japan.
  5. There are no conflicts of interest to declare.

Abstract

The fat mass and obesity-associated (FTO) gene has recently attracted attention as one of the obesity-related genes. Obesity-related gene polymorphisms may be associated with the development of atherothrombosis in relation to platelets. The present study investigated the association between FTO gene polymorphisms (rs1558902, T/A) and hematological parameters, in particular the platelet counts. Anthropometric, hematological, and biochemical parameters, in addition to genotyping by an allele-specific DNA assay, were measured in 209 asymptomatic community-dwelling Japanese subjects (male/female: 80/129; mean age, 65 years; mean [SD] body mass index, 24.0 [3.0] kg/m2). The subjects with the A-allele (n = 73) showed significantly higher platelet counts than those without the A-allele (mean [SD], 237 [58] vs 217 [57] × 109/L, P < 0.05). Even when multiple-adjusted analyses were performed, the platelet counts continued to differ significantly and independently of other variables, including obesity-related parameters such as the index of insulin resistance or high-sensitivity C-reactive protein, between the subjects with and without the A-allele. The FTO gene polymorphisms may be associated with the minor but significant modulation of platelet counts in this population.

Key Words
  • obesity
  • fat mass and obesity-associated gene
  • atherothrombosis
  • atherosclerosis
  • insulin resistance

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.