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SINGLE CELL STUDIES IN AGING RESEARCH (R01): (PA-11-320)

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Also note: Single Cell Studies in Aging Research (R21): (PA-11-321)

Details at: http://grants.nih.gov/grants/guide/pa-files/PA-11-321.html

Components of Participating Organizations

National Institute on Aging

Application Receipt/Submission Date(s): Multiple dates, see announcement.

The primary aim for this Funding Opportunity Announcement (FOA) is to encourage the submission of research projects that would advance biomedical research at the single cell level, facilitating the identification of molecular and cellular markers of normal aging and in disease progression during aging; and to advance the understanding of the impact of cellular heterogeneity during aging across a broad range of cell types and disease states.

Cellular behavior has traditionally been investigated by utilizing bulk-scale methods that measure average values for population of cells. Such population-wide studies mask the behavior of individual cells and are often insufficient for characterizing the biological processes in which cellular heterogeneity plays a key role. Populations of cells are almost always heterogeneous in function and fate. Cell heterogeneity is a feature that is intrinsic to many cell-fate processes, including cell division, apoptosis, and the generation of induced pluripotent stem cells. Cell signaling and transcription are also dynamic, often resulting in heterogeneous responses among cells. To understand fully the cellular specificity and complexity of tissue microenvironments under physiological conditions, it is necessary to measure molecular signatures with single cell resolution. By studying single cells at the molecular level it will be possible to obtain fingerprints of bioprocesses from different cell types and disease states and to assess how individual cells change the response to various challenges by altering the level of these biological processes in a cell-unique, yet coordinated manner. The insights into the biology of single cells will have important implications for the study of tissue and organ homeostasis during aging.

New technologies are making it possible to probe gene expression, DNA integrity, protein damage, and …

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