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GEORGE M. O'BRIEN KIDNEY RESEARCH CORE CENTERS (P30): RFA-DK-11-008

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National Institute of Diabetes and Digestive and Kidney Diseases

Application Receipt Date(s): November 15, 2011

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) invites applications for George M. O'Brien Kidney Research Core Centers to support both basic and clinical research on kidney disease. Core Centers should provide shared institutional and national resources to facilitate basic and clinical research on kidney disease and improve the effectiveness of translating insights from basic biology to clinical practice. The Centers will also support pilot and feasibility studies to develop and test innovative approaches to therapy.

Much progress has been made since the initial solicitation for O'Brien Kidney Research Centers in 1987. This program not only allows for, but encourages regional, national and even international collaboration. While there is still no cure for chronic kidney disease, the number of patients progressing to kidney failure now appears to be stabilizing, (possibly even decreasing). Despite this trend in the overall population, however, the same down turn in disease incidence has not been realized in minority populations. Additionally, while there are new genetic findings that explain some of the increased risk for disease, many challenges remain in determining the pathophysiologic mechanisms of kidney disease that could potentially be targeted for therapeutic interventions. Similarly, acute kidney injury (AKI) remains an important clinical problem. Although important advances have been made in understanding AKI in animals, translating that knowledge from experimental models to humans is complicated by its heterogeneity, and has fallen short of expected goals of impacting on the morbidity and mortality of this disease.

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) currently supports through the Division of Kidney, Urologic and Hematologic Diseases (DKUHD) eight George M. O'Brien Kidney Research Centers, two Centers of Excellence in Pediatric Nephrology, and …

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