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Nonerythropoietic Properties of Erythropoietin
  1. Dhanesh B. Rathod, MD, MPH,
  2. Abdulla K. Salahudeen, MD
  1. From the Nephrology Section, Department of General Internal Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX.
  1. Received May 9, 2011, and in revised form July 5, 2011.
  2. Accepted for publication July 6, 2011.
  3. Reprints: Abdulla K. Salahudeen, MD, Department of General Internal Medicine AT&EC, 1515 Holcombe Blvd, Box 1465, Houston TX 77030. E-mail: aksalahudeen{at}
  4. Dr. Salahudeen had received a grant support from Amgen Inc for an investigator-initiated grant proposal.

Implication for Tissue Protection


Erythropoietin (EPO) is used at present in clinical practice to stimulate red cell production. However, a number of reports have emerged suggesting the presence of nonerythropoietic properties for EPO. Chief among them is its ability to confer protection against acute tissue injury. In this report, we briefly review the role of EPO in tissue protection and provide examples of tissue protection using cisplatin-induced kidney injury model. Also provided is a brief description of potential pathways through which EPO may be mediating this effect.

Key Words
  • cell injury
  • erythropoietin
  • tissue protection

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