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Recent Insights Into the Relationship Between Inflammatory Liver Diseases and Atherosclerosis
  1. Tugrul Purnak, MD*,
  2. Cumali Efe, MD,
  3. Yavuz Beyazit, MD,
  4. Ersan Ozaslan, MD*,
  5. Ramazan Astan, MD§,
  6. Aysel Milanlıoglu, MD,
  7. Zeynep Ozbalkan, MD,
  8. Manfredi Rizzo, MD, PhD**
  1. From the *Department of Gastroenterology, Ankara Numune Education and Research Hospital; †Department of Gastroenterology, Hacettepe University School of Medicine; ‡Department of Gastroenterology, Yuksek Ihtisas Education and Research Hospital, Ankara; §Department of Cardiology, Tatvan State Hospital; ∥Department of Neurology, Bitlis State Hospital, Bitlis; ¶Department of Rheumatology, Ankara Numune Education and Research Hospital,Ankara; and **Department of Clinical Medicine and Emerging Diseases, University of Palermo, Palermo, Italy.
  1. Received December 9, 2010, and in revised form February 11, 2011.
  2. Accepted for publication February 24, 2011.
  3. Reprints: Cumali Efe, MD, Department of Gastroenterology, Hacettepe University School of Medicine, 06100 Sihhiye, Ankara, Turkey. E-mail: drcumi21{at}
  4. There is no conflict of interest to declare.


Atherosclerosis is a dynamic process in the human body. Many studies have evaluated atherosclerosis and its relationship with other systems in the body. Our perception of its pathogenesis is evolving with the introduction of new players in the game. It is no longer possible to consider the atherosclerosis as an independent process, unaffected by the liver and its function. Although several tasks performed by the liver, such as lipid metabolism, have been implicated in the pathogenesis of atherosclerosis, the role of other disorders of the liver (autoimmune diseases, viral hepatitis, and cirrhosis) are not fully understood. In this review, the most commonly encountered inflammatory liver diseases and their effects on atherosclerosis are discussed.

Key Words
  • hepatitis B
  • hepatitis C
  • hepatitis A
  • inflammation
  • fatty liver
  • atherosclerosis
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