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CHEMICAL APPROACHES TO TARGET VALIDATION FOR DRUG RESISTANT PATHOGENS (R01): RFA-AI-11-004

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Components of Participating Organizations

National Institute of Allergy and Infectious Diseases

Application Receipt Date(s): June 15, 2011

The National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) supports extramural research focused on understanding, controlling and preventing human disease caused by human infectious agents. Through the increase in drug resistance in clinically relevant pathogens (e.g. those for which drug resistance has been documented and new anti-infective agents are critically needed), there is an urgent need to define physiological pathways in pathogens and complementary pathways in the host and to define relevant, and chemically validated biological targets for use in developing treatments for infectious diseases.

Through this FOA, the NIAID invites applications for research focused on using chemical tools to either address scientific questions about microbial biological processes and host-pathogen interactions and/or determine the biological activity of host or pathogen proteins. Rather than focusing on identifying medicinal products, a broader approach of analyzing biological targets that can serve as the basis for future chemical screens to identify drug candidates as well as contribute to functional annotation of gene products should be taken.

At the end of the project period, a successful project will either contribute substantial data to the characterization of a biological drug target (in vitro and/or in vivo) or will have contributed to the functional annotation of pathogen genes and pathways. Projects must assess the potential of a target to be inhibited by a chemical entity. This inhibition should result in decreased or abolished viability of the pathogen in vitro (microbial viability) and/or in vivo (lack of growth or establishment of pathology in animal models). It is expected that projects will also contribute to the functional annotation of gene products and biochemical signaling pathways relevant to infectious disease.

A key component of this initiative is the …

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