Article Text

Lack of Association Between the IL-10 Gene Polymorphisms and Features of the Metabolic Syndrome
  1. Ming-Ying Lu, MD, PhD*,
  2. Bhaskar V.K.S. Lakkakula, MD, PhD,
  3. Yi-Chu Liao, MD, PhD*‡,
  4. Pei-Chien Tsai, MD, PhD§∥,
  5. Yi-Hsin Yang, MD, PhD§∥,
  6. Suh-Hang Hank Juo, MD, PhD§¶
  1. From the *Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; †Department of Biomedical Sciences, Sri Ramachandra University, Chennai, India; ‡Section of Neurology, Taichung Veterans General Hospital, Taichung; §Department of Medical Research, Kaohsiung Medical University Hospital; and Departments of ∥Oral Hygiene, and ¶Medical Genetics, Kaohsiung Medical University, Kaohsiung, Taiwan.
  1. Received September 6, 2010, and in revised form October 16, 2010.
  2. Accepted for publication November 3, 2010.
  3. Reprints: Suh-Hang Hank Juo, MD, PhD, Department of Medical Genetics, Kaohsiung Medical University Hospital, No. 100, Tzyou 1st Rd, Kaohsiung 807, Taiwan. E-mail: hjuo{at}
  4. Supported by the grants from National Science Council (NSC95-2314-B-037-020) and National Health Research Institutes (NHRI-Ex96-9607PI).
  5. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (


Backgrounds Insulin resistance plays a major role in the pathogenesis of the metabolic syndrome. Inflammation is the leading cause of insulin resistance, and interleukin 10 (IL-10) is one of the anti-inflammatory cytokines. We conducted a case-control study to investigate the association between the IL-10 polymorphisms and the metabolic syndrome.

Methods One thousand two hundred two unrelated subjects residing in southern Taiwan were retrospectively recruited from a community-based health screening program. Two hundred sixty subjects were defined as the metabolic syndrome (3-5 risk components) and 549 subjects as controls (0-1 risk component) on the basis of the Asian version of the Adult Treatment Panel III criteria. A functional IL-10 single nucleotide polymorphism (SNP; rs1800871) and 2 tagging SNPs (rs3790622, rs3021094) were genotyped by TaqMan method.

Results We analyzed the association between the genotypes and the presence of the metabolic syndrome or metabolic traits by χ 2 test and multivariant logistic regression. None of the IL-10 SNPs were found to be significantly related with the metabolic syndrome or its risk components. All the 3 SNPs were in single linkage disequilibrium block. Haplotype analysis did not yield significant association between IL-10 gene and the metabolic syndrome (global P = 0.88).

Conclusions Because we used tagging SNPs and a modest clinical cohort, we concluded that the IL-10 gene polymorphisms may be unlikely to play an important role for the metabolic syndrome.

Key Words
  • IL-10
  • single nucleotide polymorphism (SNP)
  • metabolic syndrome

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