Article Text

PDF
Low Level of Serum Interleukin 27 in Patients With Systemic Lupus Erythematosus
  1. Ting-Ting Li, MM*,
  2. Tao Zhang, MM*,
  3. Gui-Mei Chen, MM*,
  4. Qing-Qing Zhu, MM*,
  5. Jin-Hui Tao, MM*†,
  6. Hai-Feng Pan, MD*,
  7. Dong-Qing Ye, MD*
  1. From the *Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University; and †Department of Rheumatology, Anhui Provincial Hospital, Hefei, Anhui, PR China.
  1. Received November 21, 2009, and in revised form February 2, 2010.
  2. Accepted for publication February 9, 2010.
  3. Reprints: Dong-Qing Ye, MD, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, PR China. E-mail: ydq{at}ahmu.edu.cn.
  4. Li and Zhang contributed equally to this work and should be considered as co-first authors.
  5. Supported by grants from the key program of the National Natural Science Foundation of China (30830089 and 30771848).

Abstract

T helper 17 (TH17) cells are beginning to be implicated in the pathogenesis of systemic lupus erythematosus (SLE). Recent studies have shown that interleukin 27 (IL-27) controls the development of TH17. However, whether IL-27 plays a role in the development of SLE is still unclear. In the present work, we investigated the serum IL-27 level in SLE and its relations to disease activity. Fifty-six patients with SLE and 30 healthy volunteers were recruited. Serum IL-27 levels were detected by enzyme-linked immunosorbent assay. The clinical and laboratory parameters were collected from medical records or by questionnaire. The serum IL-27 level in SLE patients was significantly lower than that in healthy controls (P < 0.001). Compared with SLE patients without nephritis, patients with nephritis had a significantly decreased serum IL-27 level (P < 0.05). However, there was no significant difference between less active and more active SLE (P > 0.05). Correlation analysis between serum IL-27 levels and SLE disease activity index showed no association (P > 0.05). In summary, a decrease in serum IL-27 level in patients with SLE suggested that this cytokine might be implicated in the pathomechanism of this disease.

Key Words
  • IL-27
  • T helper 17 cells
  • systemic lupus erythematosus

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.