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DEEP SEQUENCING AND ANALYSIS OF PHARMACOGENOMIC REGIONS: DISCOVERY AND ANALYSIS OF GENETIC VARIANTS CONTRIBUTING TO DRUG ABUSE AND ADDICTION (R01): RFA-DA-10-019

Components of Participating Organzations

National Institute on Drug Abuse

Application Due Date: April 29, 2010

Genome-wide association studies (GWAS) have been critical for identifying genomic regions associated with addiction phenotypes, and have highlighted several areas that require further refinement using deep sequencing approaches. The goal of this FOA is to support studies proposing to use next-generation sequencing technologies to identify the structural variants and SNP variants with rare to moderate frequencies that affect addiction risk in well-characterized samples with drug abuse phenotypes. Applications may propose strategies for deep sequencing based on family based designs; deep sequencing of regions identified by GWAS to be associated with addiction risk; sequencing candidate genes in individuals with extreme phenotypes; or other analytic approaches that capitalize on the genetic architecture. Applicants must use existing DNA samples with appropriately obtained consents for broad data sharing.

This FOA will utilize the R01 award mechanism. The total amount to be awarded for this FOA will be up to $10M in total costs per year, with the anticipated number of awards ranging from 1-4. Budgets for direct costs of up to $2.5M per year and a project duration of up to five years may be requested.

Eligible institutions and organizations include: public or state controlled institutions of higher education; private institutions of higher education; Hispanic-serving institutions; Historically Black Colleges and Universities; Tribally Controlled Colleges and Universities; Alaska native- and native Hawaiian- serving institutions; nonprofit organizations with 501(c)(3) IRS status (other than institutions of higher education); nonprofit organizations without 501(c)(3) IRS status (other than institutions of higher education); small businesses; for-profit organizations (other than small businesses); state governments; Indian/Native American tribal governments (federally recognized); Indian/Native American tribally designated organizations; county governments; City or township governments; special district governments; Independent School Districts; Public housing authorities/Indian housing authorities; U.S. territories or possessions; …

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