Article Text

Download PDFPDF
Integrins, Focal Adhesions, and Cardiac Fibroblasts
  1. Ana Maria Manso, PhD*†,
  2. Seok-Min Kang, MD, PhD*†‡,
  3. Robert S. Ross, MD*†
  1. From the *Department of Medicine, UCSD School of Medicine, La Jolla, CA; †Veterans Administration Healthcare, San Diego, CA; and ‡Cardiology Division, Yonsei University College of Medicine, Seoul, Korea.
  1. Received September 9, 2009.
  2. Accepted for publication September 25, 2009.
  3. Reprints: Robert S. Ross, MD, VA San Diego Healthcare System, 3350 La Jolla Village Dr, Cardiology Section, 111A, San Diego, CA 92161. E-mail: rross{at}
  4. Supported by grants from the Veterans Administration (VA Merit) and the National Institutes of Health (P01 HL066941 and RO1 HL088390) to R.S.R., and the symposium was supported in part by a grant from the National Center for Research Resources (R13 RR023236).


How the myocardium undergoes geometric, structural, and molecular alterations that result in an end phenotype as might be seen in patients with dilated cardiomyopathy or after myocardial infarction is still poorly understood. Structural modification of the left ventricle, which occurs during these pathological states, results from long-term changes in loading conditions and is commonly referred to as "remodeling." Remodeling may occur from increased wall stress in the face of hypertensive heart disease, valvular disease, or, perhaps most dramatically, after permanent coronary occlusion. A fundamental derangement of myocyte function is the most common perception for the basis of remodeling, but the role of cells in the heart other than the muscle cell must, of course, be considered. Although studies of the myocyte have been extensive, cardiac fibroblasts have been studied less than myocytes. The fibroblast has a broad range of functions in the myocardium ranging from elaboration and remodeling of the extracellular matrix to communication of a range of signals within the heart, including electrical, chemical, and mechanical ones. Integrins are cell surface receptors that are instrumental in mediating cell-matrix interactions in all cells of the organism, including all types within the myocardium. This review will focus on the role of integrins and related proteins in the remodeling process, with a particular emphasis on the cardiac fibroblast. We will illustrate this function by drawing on 2 unique mouse models with perturbation of proteins linked to integrin function.

Key Words
  • integrin function
  • cardiac fibroblasts

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.