Article Text
EB Symposium
Central Leptin Receptor Action and Resistance in Obesity
Abstract
The discovery of leptin in 1994 has led to remarkable advances in obesity research. We now know that leptin is a cytokinelike hormone that is produced in adipose tissue and plays a pivotal role in regulation of energy balance and in a variety of additional processes via actions in the central nervous system. This symposium review covers current understandings of neuronal leptin receptor signaling and mechanisms of obesity-related leptin resistance in the central nervous system and provides recent insights into the regulation of peripheral glucose balance by central leptin action in rodents.
- leptin
- receptor
- hypothalamus
- signaling
- POMC
- neurons
- obesity
- diabetes
- rodents