Article Text

PDF
The Anti-Inflammatory Effects of Prostaglandins
  1. Jose U. Scher, MD*†,
  2. Michael H. Pillinger, MD*†
  1. From the *Division of Rheumatology, Department of Medicine, NYU School of Medicine/NYU Hospital for Joint Diseases; and †Department of Medicine, VA NY Harbor Healthcare System, NY Campus, New York, NY.
  1. Received November 4, 2008, and in revised form December 10, 2008.
  2. Accepted for publication December 10, 2008.
  3. Reprints: Michael H. Pillinger, MD, Division of Rheumatology NYU Hospital for Joint Diseases, 301 E 17th St, New York, NY 10003. E-mail: mhpillinger{at}gmail.com.
  4. This symposium was supported in part by a grant from the National Center for Research Resources (R13 RR023236).

Abstract

Long regarded as proinflammatory molecules, prostaglandins (PGs) also have anti-inflammatory effects. Both prostaglandin D2 (PGD2) and its dehydration end product 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) seem to play important roles in regulating inflammation, via both receptor-dependent (DP1 and DP2 receptors) and receptor-independent mechanisms. Intracellular effects of PGD2 and 15d-PGJ2 that may suppress inflammation include inhibition of nuclear factor-κB (NF-κB) by multiple mechanisms (IκB kinase inhibition and blockade of NF-κB nuclear binding) and activation of peroxisome proliferator-activated receptor-γ (PPAR-γ). Prostaglandin F (PGF) may also have important anti-inflammatory effects, although current data are limited. In animal models, expression of both PGD and PGF synthases declines during acute inflammation, only to rise again during the resolution phase, suggesting their possible role in resolving inflammation. Prostaglandin E2 (PGE2), the classic model of a proinflammatory lipid mediator, also has anti-inflammatory effects that are both potent and context dependent. Thus, accumulating data suggest that PGs not only participate in initiation, but may also actively contribute to the resolution of inflammation. Indeed, classic inhibitors of PG synthesis such as nonselective and cyclooxygenase-2 (COX-2) selective inhibitors (nonsteroidal anti-inflammatory drugs) may actually prolong inflammation when administered during the resolution phase. These effects may regulate not only tissue inflammation but also vascular disease, possibly shedding light on the controversy surrounding nonsteroidal anti-inflammatory drug use and its relation to myocardial infarction. In this review, we summarize the current understanding of PGs as dichotomous molecules in the inflammatory process.

Key Words
  • prostaglandin
  • inflammation
  • cardiovascular disease
  • NSAID
  • cyclooxygenase

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.