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1: VITAMIN D INSUFFICIENCY IN AFRICAN AMERICAN CHILDREN WITH FOREARM FRACTURES
L.M. Ryan1,2, R. Freishtat1, J. Wright1,2,5, J. Chamberlain1,2, C. Brandoli3, L. Tosi3, R. Freishtat4, E. Hoffman4. 1Emergency Medicine, Children's National Medical Center, Washington, DC; 2Research Center for Health Services and Community Research, Children's National Medical Center, Washington, DC; 3Orthopaedics and Sports Medicine, Children's National Medical Center, Washington, DC; 4Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC; and 5Child Health Advocacy Institute, Children's National Medical Center, Washington, DC.
Purpose of Study
Half of all children fracture a bone; of those, nearly 40% sustain additional fractures. Fracture rates are increasing. Poor vitamin D status increases fracture risk in infants and adults. The relationship between vitamin D status and childhood fractures has not been investigated. We hypothesize that pediatric fracture cases have an increased prevalence of vitamin D insufficiency compared to fracture-free controls.
This case-control study is enrolling cases (African American children, ages 5-9 years, with forearm fracture) and fracture-free controls. Evaluation includes measurement of serum 25-hydroxy vitamin D level and BMD by dual energy xray absorptiometry (DXA) scan. Univariable and multivariable analyses are used to test the associations between fracture status and the independent variables serum vitamin D level and BMD with control for confounders.
Summary of Results
To date, 31 cases and 7 controls are enrolled. The mean ± SD case age is 7.2 ± 1.4 years; 55% are male. The mean control age is 6.4 ± 1.3 years; 57% are male. The mean 25-hydroxy vitamin D level for cases is 21.5 ± 7 ng/mL (n=23). This mean is at the cutpoint for vitamin D insufficiency [serum 25-hydroxy vitamin D level<20 ng/mL]. Ten cases (43%) are vitamin D insufficient. The mean 25-hydroxy vitamin D level for controls is 29 ± 3.3 ng/mL (n=4) …
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