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Cardiovascular Club: Mentored Oral Presentation 11:00 AM Thursday, February 21, 2008

1 THE PREDICTIVE VALUE OF LEFT ATRIAL SIZE FOR INCIDENT ISCHEMIC STROKE AND ALL-CAUSE MORTALITY IN AFRICAN AMERICANS: THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC)STUDY

H.S. Nagarajarao, A.D. Penman, H.A. Taylor, T. Mosley, K. Butler, T. Skelton, T. Samdarchi, and E.R. Fox. University of Mississippi Medical Center, Jackson, MS.

Purpose of Study

The association between left atrial (LA) size, ischemic stroke and death has been investigated in non-Hispanic whites but not in African Americans despite their disproportionately higher rates of stroke and cardiovascular mortality.

Methods Used

Participants in the Jackson cohort of the Atherosclerosis Risk in Communities study have had extensive baseline evaluations, echocardiograms during the third examination (1993-1995), and have been followed for incident ischemic stroke and all-cause mortality.

Summary of Results

Of total 1887 participants 65% were women and had a mean age ± SD of 58.9 ± 5.7 years. LA diameter by tertile was significantly related to hypertension, diabetes and body mass index (BMI) (p<0.0001 for each). Over a median follow-up of 8.8 years for ischemic stroke and 8.9 years for all-cause mortality, there were a total of 103 strokes (6.47 per 1,000 person-years) and 206 deaths (13.3 per 1,000 person-years). After adjusting for age, sex, cigarette smoking, diabetes, hypertension, BMI, total cholesterol: HDL ratio, and triglycerides in a multivariable model, LA size was significantly related to ischemic stroke and all-cause mortality (hazard ratio (HR) 1.58; 95% CI: 1.09, 2.29, p=0.02 and HR 1.47; 95% CI: 1.13, 1.91, p=0.004 respectively). After further adjustment for left ventricular hypertrophy (LV) hypertrophy. LA size remained significantly related to all-cause mortality (HR 1.40; 95% CI: 1.07, 1.82, p=0.01).

Conclusions

In this population based cohort of African Americans echocardiographic LA size was significantly associated with all-cause mortality after adjusting for traditional cardiovascular risk factors and echocardiographic LV hypertrophy.

2 OBESITY IS THE MAJOR PREDICTOR FOR DEVELOPMENT OF LEFT VENTRICULAR REMODELING IN YOUNG ADULTS: BOGALUSA HEART STUDY

A. Toprak, H. Wang, S. Srinivasan, W. Chen, T. Paul, and G. Berenson. Tulane Center for Cardiovascular Health, New Orleans, LA.

Purpose of Study

Left ventricular structural alterations are associated …

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