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Biomarkers of Acute Kidney Injury
  1. Chirag R. Parikh,
  2. Charles L. Edelstein,
  3. Prasad Devarajan,
  4. Lloyd Cantley
  1. From the Section of Nephrology (C.R.P., L.C.), Department of Medicine, Yale University School of Medicine, New Haven, CT; Clinical Epidemiology Research Center (C.R.P.), Veterans Affairs Medical Center, West Haven, CT; Division of Renal Diseases (C.L.E.), University of Colorado Health Sciences Center, Denver, CO; Cincinnati Children's Hospital Medical Center (P.D.), University of Cincinnati, Cincinnati, OH.
  1. All authors contributed equally to this article.
  2. This symposium was supported by the Society of American Federation of Medical Research, the NIH, and Abbott Diagnostics. This publication was made possible by Grant Number 1 R13 RR023236-01 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH). Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NCRR or NIH.
  3. Address correspondence to: Dr. Chirag R. Parikh, Clinical Epidemiology Research Center, 950 Campbell Avenue, Mail Box 151B, Bldg 35A, Room 219, West Haven, CT 06492; e-mail: chirag.parikh{at}yale.edu.

Early Diagnosis, Pathogenesis, and Recovery

Abstract

This review article represents the proceedings from the translational research symposium presented at the Federation of American Societies for Experimental Biology/American Federation for Medical Research (FASEB/AFMR) meeting in May 2007 in Washington, DC. This research symposium consisted of four talks, which are individually summarized below. The first talk gave a general overview of the biomarkers in the setting of acute kidney injury (AKI), along with some data from clinical biomarker studies. The second talk discussed the preclinical studies of the emerging biomarkers in the area of AKI. The third talk discussed the biomarkers of AKI after deceased kidney transplantation, which is a unique model of kidney ischemia-reperfusion injury. The final talk discussed the role of circulating stem cells in renal tubule regeneration after ischemic injury and if they have potential for biomarkers of recovery or therapeutic intervention.

Key words
  • renal failure
  • translational research
  • stem cells
  • delayed graft function
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