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National Institutes of Health (NIH)

This request for applications (RFA) is developed as a Roadmap initiative. All NIH Institutes and Centers participate in Roadmap initiatives. This RFA will be administered by the National Center for Research Resources on behalf of the NIH.

Release date: March 22, 2007

Letter of intent receipt date: September 24, 2007

Application receipt date: October 24, 2007

The ever-increasing complexities involved in conducting clinical research are making it more difficult to translate new knowledge to the clinic-and back again to the bench. These challenges are limiting professional interest in the field and hampering the clinical research enterprise at a time when it should be expanding. The purpose of this initiative is to assist institutions to create a uniquely transformative, novel, and integrative academic home for clinical and translational science that has the resources to train and advance a cadre of well-trained multi- and interdisciplinary investigators and research teams with access to innovative research tools and information technologies to promote the application of new knowledge and techniques to patient care. Clinical and Translational Science Awards (CTSAs) will attract basic, translational, and clinical investigators; community clinicians; clinical practices; networks; professional societies; and industry to develop new professional interactions, programs, and research projects. Through innovative advanced degree programs, CTSAs will foster a new discipline of clinical and translational science that will be much broader and deeper than their separate components (the definitions of clinical and translational science are provided in Section I.1 of this document). To succeed, CTSAs will need institutional support and the status of a major administrative entity within the applicant institution, as well as a principal investigator (PI) who has authority, perhaps shared with other high-level institutional officials, over requisite space, resources, faculty appointments, protected time, and promotion. NIH anticipates that diverse models will be proposed …

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