Article Text

Download PDFPDF
Relationship between the Soluble F11 Receptor and Markers of Inflammation in Hemodialysis Patients
  1. Moro O. Salifu,
  2. Quirine Kolff,
  3. Preethi Murty,
  4. Dhiren M. Haria,
  5. Mahamadu Zimpa,
  6. Muhammad Shakeel,
  7. Howon Lee,
  8. Elizabeth Kornecki,
  9. Anna Babinska
  1. From the Department of Medicine (M.O.S., Q.K., P.M., D.M.H., M.Z., M.S., H.L.), Division of Nephrology, and Department of Anatomy and Cell Biology (E.K., A.B.), SUNY Downstate Medical Center, Brooklyn, NY.
  1. This study was funded by Institutional Grant #30132, SUNY Downstate Medical Center.
  2. Address correspondence to: Dr. Moro O. Salifu, SUNY Downstate Medical Center, 450 Clarkson Avenue, Box 52, Brooklyn, NY 11203; e-mail: moro{at}


Background The human F11 receptor (F11R) is an important cell adhesion molecule implicated in inflammatory thrombosis. We hypothesize that serum levels of the soluble released form of F11R (sF11R) are elevated in dialysis patients since these patients have higher cardiovascular disease burdens than the general population. In this study, we examined whether sF11R levels were elevated in hemodialysis (HD) patients and correlated with known inflammatory cytokines.

Methods We used new and standard enzyme-linked immunosorbent assay techniques to measure levels of sF11R, as well as high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10), in a cross section of 52 HD patients and compared these with 15 healthy controls.

Results The mean age of the patients was 56 ± 17.3 years; 60% were female, and 36% had diabetes mellitus. Serum levels of sF11R, hs-CRP, TNF-α, IL-6, and IL-10 were all significantly higher in patients than in control sera (p < .05). Within the patient group, there was a significant positive correlation between sF11R and TNF-α (r = .41, p = .003), IL-10 (r = .32, p = .023), and IL-6 (r = .32, p = .023), whereas hs-CRP showed no significant correlation (r = −.27, p = .052).

Conclusion We conclude that the sF11R level is elevated in HD patients and correlates with known markers of cardiovascular disease. sF11R may be a novel cardiovascular risk marker, and longitudinal studies are needed to better assess its relationship with cardiovascular disease morbidity and mortality in this population.

Key words
  • hemodialysis
  • F11 receptor
  • junctional adhesion molecule A
  • tumor necrosis factor
  • interleukin-6
  • cardiovascular disease

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.