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Atherosclerosis
  1. Allison B. Reiss,
  2. Amy D. Glass
  1. 1From the Vascular Biology Institute (A.B.R., A.D.G.), Winthrop University Hospital, Mineola, NY.
  1. Address correspondence to: Dr. Allison B. Reiss, Vascular Biology Institute, Winthrop University Hospital, 222 Station Plaza, North, Suite 511-A, Mineola, NY 11501; e-mail: AReiss{at}Winthrop.org
  2. Supported by a grant from the National Institutes of Health/National Heart, Lung, and Blood Institute (HL073814).
  3. American Federation for Medical Research Translational Symposium presented at Experimental Biology/IUPS 2005, San Diego, CA, April 4, 2005.

Immune and Inflammatory Aspects

Abstract

This review article discusses the historical origin of our continuously evolving model of the etiology of atherosclerotic cardiovascular disease. The basic molecular biologic concepts underlying the development of coronary artery disease and the dynamic connection between the immune system and arterial integrity are explored. Emphasis is placed on the role of inflammation as a driving force in the process of atherosclerosis and vascular endothelium as a modulating factor in the pathogenesis of coronary artery disease.

Key Words
  • atherosclerosis
  • cholesterol 27-hydroxylase
  • interferon-γ
  • macrophage
  • adenosine

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