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266 NON-HIGH-DENSITY LIPOPROTEIN CHOLESTEROL IN THE METABOLIC SYNDROME.
  1. J. Huang1,
  2. R. Parish2,
  3. H. Yu3,
  4. P. F. Bass1,
  5. I. Mansi1,
  6. E. Kennen1,
  7. T. Davis1,
  8. D. Carden1
  1. 1Louisiana State University Health Sciences Center, Shreveport, LA
  2. 2South University, Savannah, GA
  3. 3Yale University School of Medicine, New Haven, CT

Abstract

Background The metabolic syndrome (MS) refers to a cluster of risk factors, including central obesity, elevated BP, insulin resistance, and dyslipidemia (DLP) characterized by elevated triglycerides (TG) and low high-density lipoprotein cholesterol (HDL). MS currently affects 27% of US adults and is associated with increased cardiovascular morbidity and mortality. Aggressive lowering of low-density lipoprotein cholesterol (LDL) is critical in coronary artery disease (CAD) prevention. However, when TG levels are high, as often seen in MS, LDL value cannot be calculated. Non-HDL cholesterol (total cholesterol (TC) - HDL) is a measure of all apo-B containing lipoproteins with high atherogenic potential and is considered as a secondary target for lipid therapy in patients with high TG or MS. The purpose of this study was to determine the association between MS and TC, LDL, and non-HDL.

Methods Diagnosis of MS was based on NCEP criteria among 928 outpatients in a public hospital. t-Test was used for comparison of lipid components between those with and without MS.

Results Seventy percent of patients were black, 68% female; 53% had MS. Among MS patients, 87% had TG > 150 (mg/dL); 85% low HDL; 63% TC > 200; 64% LDL > 100; 69% non-HDL > 130. The results of statistical analysis are as follows:

Conclusions The prevalence of MS is high in this patient population. The prevalence of DLP is high in patients with MS. Besides TG and HDL, only non-HDL, but not TC or LDL, is significantly associated with MS. These results suggest that use of non-HDL as the therapeutic target for lipid management is appropriate in MS patients when LDL is not calculable.

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