Ziprasidone is a new atypical antipsychotic medication used in the treatment of schizophrenia and other severe psychiatric illnesses. Minimal data is available on safety in pregnancy and no cases in the literature describe prenatal exposure to this medication. The purpose of this abstract is to present a child prenatally exposed to ziprasidone who has a pattern of malformation consisting of mild midface hypoplasia, hypoplastic nails, hypoplastic distal fingertips, bilateral 5th fingers clinodactyly, short fourth toes and symmetric growth deficiency, features described in infants exposed to other anti-epileptic medications. Furthermore, since this drug may induce ventricular arrhythmias, it is suggested that the defects seen in this child may be the result of fetal arrhythmias resulting in hypoxia/reperfusion injury to susceptible tissues.
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