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Gluconeogenesis and Glycogenolysis in Health and Diabetes
  1. Guenther Boden
  1. From the Division of Endocrinology/Diabetes/Metabolism, Temple University School of Medicine, Philadelphia, PA.
  2. Presented in part at the American Federation for Medical Research-sponsored symposium during Experimental Biology 2004, Washington, DC, April 17-21, 2004.
  3. Supported by National Institutes of Health grants R01-AG15363, R01-DK058895, R01-HL073267, and R01-DK066003 and a mentor-based training grant from the American Diabetes Association.
  4. Address correspondence to: Dr. Guenther Boden, Temple University Hospital, 3401 North Broad Street, Philadelphia, PA 19140; e-mail: bodengh{at}


Reviewed are data on gluconeogenesis (GNG) and glycogenolysis (GL) obtained in healthy volunteers and diabetic patients with newer, quantitative methods. Specifically addressed are effects of overnight and prolonged fasting, of acute changes in serum insulin and plasma free fatty acid (FFA) levels, as well as acute changes of combined FFA and insulin levels on GNG and GL in nondiabetic subjects and of abnormalities in GNG and GL in patients with type 1 and type 2 diabetes.

Key Words
  • gluconeogenesis
  • glucogenolysis
  • free fatty acids
  • endogenous glucose production

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