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Oxidative Stress and Antioxidant Supplementation in the Management of Diabetic Cardiovascular Disease
  1. Sonia Vega-López,
  2. Sridevi Devaraj,
  3. Ishwarlal Jialal
  1. From the Laboratory for Atherosclerosis and Metabolic Research (S.V.-L., S.D., I.J.), University of California, Davis Medical Center, Sacramento, CA.
  1. Address correspondence to: Dr. Ishwarlal Jialal, Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, CA 95817; E-mail: ishwarlal.jialal{at}ucdmc.ucdavis.edu.
  2. Presented in part at the American Federation for Medical Research-sponsored symposium during Experimental Biology 2003: Translating the Genome, San Diego, CA, April 11-15, 2003.
  3. Supported in part by a grant from the National Institutes of Health, K24 AT00596.

Abstract

The diabetic state confers an increased propensity to accelerated atherogenesis. In addition to the established risk factors, there is evidence for increased oxidative stress in diabetes. Increased oxidative stress is manifested by increased lipid peroxidation, increased F2-isoprostanes, increased nitrotyrosine, and increased DNA damage. Also, in diabetics, there is increased superoxide release. With regard to diabetes, antioxidants such as α-tocopherol, α-lipoate, and ascorbic acid supplementation have been shown to be beneficial. Most importantly, α-tocopherol therapy, especially at high doses, clearly shows a benefit with regard to low-density lipoprotein oxidation, isoprostanes, and monocyte superoxide release. Thus, it appears that, in diabetes, antioxidant therapy could alleviate the increased attendant oxidative stress and emerge as an additional therapeutic modality.

Key Words
  • diabetes
  • oxidation
  • isoprostane
  • antioxidant
  • vitamin E

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