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Newly Emerging Concepts in Blood Vessel Growth: Recent Discovery of Endothelial Progenitor Cells and Their Function in Tissue Regeneration
  1. Oren M. Tepper,
  2. Brett A. Sealove,
  3. Toshinori Murayama,
  4. Takayuki Asahara
  1. From Department of Surgery the Institute of Reconstructive Plastic Surgery (O.M.T.), New York University Medical Center, New York, New York; Department of Medicine (B.A.S.), Mount Sinai Hospital, New York, New York; Cardiovascular Research (T.M., T.A.), St. Elizabeth's Medical Center, Boston, Massachusetts; Stem Cell Translational Research (T.A.), Institute of Biomedical Research and Innovation/RIKEN Center for Developmental Biology, Kobe, Japan, and Physiology, Tokai University School of Medicine, Isehara, Japan.
  1. Address correspondence to: Dr. Oren M. Tepper, Department of Surgery, New York University School of Medicine, 550 First Ave. BH 15-N1 New York, NY 10016; e-mail: teppeo01{at}med.nyu.edu.

Abstract

It has recently been established that bone marrow-derived endothelial progenitor cells (EPCs) are recruited to the systemic circulation and, in response to various cytokines, pharmacologic agents, and/or tissue ischemia, incorporate into sites of new blood vessel growth (neovascularization). These findings have changed our understanding of adult neovascularization by demonstrating that both preexisting endothelial cells and EPCs contribute to blood vessel formation during adult life. The following review article highlights the discovery of EPCs, their relationship to various clinical diseases, and their therapeutic potential for augmenting blood vessel formation.

Key Words
  • endothelial progenitor cells
  • vasculogenesis
  • angiogenesis
  • therapeutic vasculogenesis
  • cell/gene therapy

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