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Serum Metalloproteinase 9 Levels in Patients with Coronary Artery Disease: A Novel Marker of Inflammation
  1. Patrizia Ferroni,
  2. Stefania Basili,
  3. Francesca Martini,
  4. Cristiano M. Cardarello,
  5. Fabrizio Ceci,
  6. Manuela Di Franco,
  7. Giuliano Bertazzoni,
  8. Pier Paolo Gazzaniga,
  9. Cesare Alessandri
  1. From the Departments of Experimental Medicine and Pathology (P.F., F.M., P.P.G., C.A.), Medical Therapy (S.B., C.M.C., M.D.F.), Cellular Biotechnology and Haematology (F.C.), and Emergency (G.B.), University of Rome La Sapienza, Rome, Italy.
  1. Presented at the 17th International Congress on Thrombosis, Bologna, Italy, October 26-30, 2002. An abstract was published in Pathophysiol Haemost Thromb 2002;32 Suppl 2:62.
  2. Address correspondence to Patrizia Ferroni, MD, PhD, Department of Experimental Medicine and Pathology, University of Rome La Sapienza, Viale Regina Elena 324, I-00I61 Rome, Italy; e-mail: patrizia.ferroni{at}


Background The finding that expression of metalloproteinases (MMPs) is induced in atherosclerotic plaques prone to rupture suggests the possibility that patients with atherosclerotic diseases would show enhanced blood levels of MMPs and that MMPs might represent a potential inflammatory risk factor for atherosclerosis. Therefore, the present study was aimed at verifying whether MMPs may represent sensitive markers of inflammation in patients with coronary artery disease.

Methods MMP-2, MMP-9, interleukin (IL)-6, C-reactive protein (CRP), and fibrinogen levels were measured in blood samples obtained from 66 cases with previous acute myocardial infarction and 66 control subjects similar for age, sex, and major atherosclerotic risk factors but without history or evidence of atherothrombotic diseases.

Results Biohumoral markers of inflammation and MMP-9 levels were significantly elevated in cases compared with controls (median values 40.6 versus 9.8 ng/mL; p < .0001), whereas MMP-2 levels did not differ between the two groups (median values 839 versus 873 ng/mL; p = .53). A direct correlation was found among MMP-9, CRP, IL-6, and fibrinogen levels. Conditional logistic regression analysis showed that MMP-9 is related to myocardial infarction (p = .006) even after adjusting for cardiovascular medications and CRP.

Conclusion These findings suggest that measurement of serum MMP-9 levels may represent a novel marker of inflammation in patients with known coronary artery disease and might provide an index of plaque activity in this clinical setting.

Key Words
  • metalloproteinases
  • atherosclerosis
  • inflammation

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