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Purpose: The National Institute on Aging (NIA) and the National Cancer Institute (NCI) invite research grant applications (R01s) for studies directed at cancer in older persons. The majority of cancers affect older persons disproportionately because aging is a high risk factor for malignant tumors. The focus for this research solicitation is on the older adult age group in the US population in which cancer primarily occurs, that is, persons aged 65 years and older. The impetus for this announcement is based on the magnitude of the cancer problem of older persons as indicated by the NCI SEER data and the expanding US aging population. Research is needed across the scientific spectrum of cancer control for early detection, diagnosis, prevention, treatment, prognosis, and survivorship. Clinical studies and the biology interface of aging and cancer research are included in this initiative. Little is known about how age-associated problems affect cancer patient evaluation, prevention and …

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