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DIET, DNA METHYLATION AND OTHER EPIGENETIC EVENTS, AND CANCER PREVENTION: RFA CA-03-016

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Purpose: The National Cancer Institute (NCI) and the ODS invite applications for new R01 and R21 grants, which are focused on research leading to the elucidation of mechanism(s) by which dietary factors influence epigenetic processes as well as increase the understanding of these processes in cancer prevention. The approach is to encourage collaboration between nutrition and epigenetic/DNA methylation experts to study bioactive food components with cancer preventive properties and to examine key epigenetic events in cancer processes (ie, carcinogen metabolism, cell division, differentiation, apoptosis) so that investigators can begin to establish linkages between epigenetics, methylation pattern, and tumor incidence/behavior. It is anticipated that the information gained will provide guidance for the development of dietary intervention strategies for cancer prevention. In addition to the present announcement, the NCI and the ODS announce a related initiative about diet, DNA methylation and other epigenetic events, and cancer prevention using an additional funding mechanism: Competing Supplements for existing NCI awardees (<http://grants.nih.gov/grants/guide/pa-files/PAR-02-175.html>), which …

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