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Purpose: The NCI and the NIDDK solicit investigator-initiated applications to promote better understanding of the pathophysiology of bone metastasis, especially as it relates to tumor cell-bone interactions. The overall goal is to delineate the role of bone microenvironment on tumor cell survival and colonization. Collaborative interactions between bone biologists, clinical oncologists, and cancer biologists are highly encouraged. These studies should contribute to a better understanding of the molecular events that account for homing of tumor cells to the bone and generating novel therapeutic reagents. Both the exploratory (R21) and traditional (R01) grant applications will be accepted.
Term/Amount: This RFA will use NIH R01 and R21 …
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