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Purpose: The purpose of this Program Announcement (PA) is to encourage basic research on the structures of membrane proteins at atomic resolution. It replaces and updates previous Program Announcements (PA-99-004 and PA-95-035) that were issued under the same title. Considerable ongoing research is being conducted in the area of membrane protein structure and function, yet relatively few investigators have applied the techniques of x-ray crystallography, electron diffraction, or nuclear magnetic resonance (NMR) spectroscopy to study the structures of their proteins directly. During the past decade, approximately 30 membrane protein structures have been solved, and each structure has been a major contributor in its area of science (see http://Blanco.biomol.uci.edu/Membrane_Proteins_xtal.html). This progress clearly demonstrates that obtaining membrane protein structures is feasible. During the same decade, however, the rate of soluble protein structure solution has accelerated greatly, and a gap remains between the understanding of membrane proteins and the understanding of their soluble protein counterparts. The Protein Structure …
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