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CHEMOPREVENTION OF TOBACCO-RELATED CANCERS IN FORMER SMOKERS: PRECLINICAL STUDIES: RFA-CA-03-004

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Purpose: New, extraordinary opportunities are defined annually in the National Cancer Institute/s Annual By-pass Budget. One of the extraordinary opportunities for several years has been the field of tobacco research. As part of the implementation plan to address this opportunity, the Division of Cancer Prevention, NCI, invites applications for new R01 and R21 grants and competitive supplements to existing grants to apply protocols that mimic the former smoker condition to preclinical animal models. Such research should be focused on 1) validating surrogate biomarkers for tobacco-related cancers in animal models under experimental protocols that mimic the high risk of former smokers and 2) identifying and prioritizing agents that prevent cancers in tobacco-susceptible organ systems using protocols that mimic the higher risk of former smokers at the time of intervention. A related RFA is anticipated that will invite applications for clinical research projects …

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