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Purpose: The National Cancer Institute (NCI) invites Applications (U54) to develop Cooperative Specialized Centers for both basic and clinical research in areas related to dietary nutrients as modifiers of genetic pathways leading to cancer. The overall goal of this initiative is to advance the science of nutrition by capitalizing on recent advances in molecular biology and genetics and by addressing three extraordinary opportunities identified in The National Cancer Institute/s 2002 Bypass Budget: Genes and the Environment, Defining the Signatures of Cancer Cells, and Molecular Targets (see http://www.cancer.gov/initiatives/). This RFA invites investigators to form interdisciplinary research teams to resolve complex gene-nutrient interrelationships that relate to cancer prevention. All research approaches are encouraged, as long as they address the following essential features: a cancer focus, institutional commitment, organizational capabilities, facilities, and interdisciplinary coordination and collaboration. Receipt of a Planning Grant Award (P20) is not a prerequisite to apply for this RFA. A team must include investigators from one or more institutions with expertise in nutrition and molecular biology and/or genetics and may contain …
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